UBE2D2-SND1 Fusion FISH Probe
The UBE2D2-SND1 Fusion FISH Probe is used to confirm a fusion of the UBE2D2 and SND1 genes. The fusion of the UBE2D2 and SND1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2D2-SND1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2D2-SND1-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE2D2 Gene Summary
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Name: Ubiquitin Conjugating Enzyme E2 D2
Chromosome: CHR5: 138940750 -139008018
Locus: 5q31.2
SND1 Gene Summary
This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]
Gene Name: Staphylococcal Nuclease And Tudor Domain Containing 1
Chromosome: CHR7: 127292201 -127732659
Locus: 7q32.1
Gene Diseases
The UBE2D2 SND1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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