UBE3A-CYP19A1 Fusion FISH Probe
The UBE3A-CYP19A1 Fusion FISH Probe is used to confirm a fusion of the UBE3A and CYP19A1 genes. The fusion of the UBE3A and CYP19A1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE3A-CYP19A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-RERE | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-REOR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-REGO | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-REGR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-OROR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GORE | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GROR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE3A-CYP19A1-20-AQAQ | 20 (40 μL) | 200 μL |
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CYP19A1 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Gene Name: Cytochrome P450 Family 19 Subfamily A Member 1
Chromosome: CHR15: 51500253 -51630795
Locus: 15q21.2
UBE3A Gene Summary
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Protein Ligase E3A
Chromosome: CHR15: 25582395 -25684175
Locus: 15q11.2
Gene Diseases
The UBE3A CYP19A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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