SEARCH OUR PRODUCT CATALOG

UBE3A-DTWD1 Fusion FISH Probe

The UBE3A-DTWD1 Fusion FISH Probe is used to confirm a fusion of the UBE3A and DTWD1 genes. The fusion of the UBE3A and DTWD1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
UBE3A-DTWD1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
UBE3A-DTWD1-20-RERE 20 (40 μL) 200 μL
UBE3A-DTWD1-20-REOR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-REGO 20 (40 μL) 200 μL
UBE3A-DTWD1-20-REGR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-REAQ 20 (40 μL) 200 μL
UBE3A-DTWD1-20-ORRE 20 (40 μL) 200 μL
UBE3A-DTWD1-20-OROR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-ORGO 20 (40 μL) 200 μL
UBE3A-DTWD1-20-ORAQ 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GORE 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GOOR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GOGO 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GOGR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GOAQ 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GRRE 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GROR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GRGO 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GRGR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-GRAQ 20 (40 μL) 200 μL
UBE3A-DTWD1-20-AQRE 20 (40 μL) 200 μL
UBE3A-DTWD1-20-AQOR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-AQGO 20 (40 μL) 200 μL
UBE3A-DTWD1-20-AQGR 20 (40 μL) 200 μL
UBE3A-DTWD1-20-AQAQ 20 (40 μL) 200 μL

UBE3A Gene Summary

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Name: Ubiquitin Protein Ligase E3A

Chromosome: CHR15: 25582395 -25684175

Locus: 15q11.2

DTWD1 Gene Summary

The DTW Domain Containing 1 (DTWD1) gene is located on chr15 :49913225-49937333 at 15q21.2.

Gene Name: DTW Domain Containing 1

Chromosome: CHR15: 49913225 -49937333

Locus: 15q21.2

Gene Diseases

The UBE3A DTWD1 Fusion has been associated with the following diseases:

Disease Name
Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.