UBE4B-PDPN Fusion FISH Probe
The UBE4B-PDPN Fusion FISH Probe is used to confirm a fusion of the UBE4B and PDPN genes. The fusion of the UBE4B and PDPN genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE4B-PDPN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-RERE | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-REOR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-REGO | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-REGR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-OROR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GORE | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GROR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE4B-PDPN-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE4B Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitination Factor E4B
Chromosome: CHR1: 10093040 -10241296
Locus: 1p36.22
PDPN Gene Summary
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Podoplanin
Chromosome: CHR1: 13910251 -13944452
Locus: 1p36.21
Gene Diseases
The UBE4B PDPN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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