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UBE4B-PLEKHG5 Fusion FISH Probe

The UBE4B-PLEKHG5 Fusion FISH Probe is used to confirm a fusion of the UBE4B and PLEKHG5 genes. The fusion of the UBE4B and PLEKHG5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
UBE4B-PLEKHG5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-RERE 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-REOR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-REGO 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-REGR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-REAQ 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-ORRE 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-OROR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-ORGO 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-ORAQ 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GORE 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GOOR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GOGO 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GOGR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GOAQ 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GRRE 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GROR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GRGO 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GRGR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-GRAQ 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-AQRE 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-AQOR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-AQGO 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-AQGR 20 (40 μL) 200 μL
UBE4B-PLEKHG5-20-AQAQ 20 (40 μL) 200 μL

UBE4B Gene Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Ubiquitination Factor E4B

Chromosome: CHR1: 10093040 -10241296

Locus: 1p36.22

PLEKHG5 Gene Summary

This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Name: Pleckstrin Homology And RhoGEF Domain Containing G5

Chromosome: CHR1: 6526151 -6580069

Locus: 1p36.31

Gene Diseases

The UBE4B PLEKHG5 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.