UBR5-TRAF3 Fusion FISH Probe
The UBR5-TRAF3 Fusion FISH Probe is used to confirm a fusion of the UBR5 and TRAF3 genes. The fusion of the UBR5 and TRAF3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBR5-TRAF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-RERE | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-REOR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-REGO | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-REGR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-REAQ | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-ORRE | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-OROR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-ORGO | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GORE | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GOOR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GOGO | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GOGR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GRRE | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GROR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GRGO | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GRGR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-AQRE | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-AQOR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-AQGO | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-AQGR | 20 (40 μL) | 200 μL |
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| UBR5-TRAF3-20-AQAQ | 20 (40 μL) | 200 μL |
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TRAF3 Gene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]
Gene Name: TNF Receptor Associated Factor 3
Chromosome: CHR14: 103243815 -103377837
Locus: 14q32.32
UBR5 Gene Summary
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Protein Ligase E3 Component N-recognin 5
Chromosome: CHR8: 103264501 -103424917
Locus: 8q22.3
Gene Diseases
The UBR5 TRAF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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