UGT1A3-CCT5 Fusion FISH Probe
The UGT1A3-CCT5 Fusion FISH Probe is used to confirm a fusion of the UGT1A3 and CCT5 genes. The fusion of the UGT1A3 and CCT5 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UGT1A3-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| UGT1A3-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
UGT1A3 Gene Summary
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]
Gene Name: UDP Glucuronosyltransferase Family 1 Member A3
Chromosome: CHR2: 234637772 -234681945
Locus: 2q37.1
Gene Diseases
The UGT1A3 CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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