UGT1A3-FGG Fusion FISH Probe
The UGT1A3-FGG Fusion FISH Probe is used to confirm a fusion of the UGT1A3 and FGG genes. The fusion of the UGT1A3 and FGG genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UGT1A3-FGG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-RERE | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-REOR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-REGO | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-REGR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-REAQ | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-ORRE | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-OROR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-ORGO | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-ORAQ | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GORE | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GOOR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GOGO | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GOGR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GOAQ | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GRRE | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GROR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GRGO | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GRGR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-GRAQ | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-AQRE | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-AQOR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-AQGO | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-AQGR | 20 (40 μL) | 200 μL |
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| UGT1A3-FGG-20-AQAQ | 20 (40 μL) | 200 μL |
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FGG Gene Summary
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Name: Fibrinogen Gamma Chain
Chromosome: CHR4: 155525285 -155533902
Locus: 4q32.1
UGT1A3 Gene Summary
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]
Gene Name: UDP Glucuronosyltransferase Family 1 Member A3
Chromosome: CHR2: 234637772 -234681945
Locus: 2q37.1
Gene Diseases
The UGT1A3 FGG Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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