VAPB-CDH12 Fusion FISH Probe
The VAPB-CDH12 Fusion FISH Probe is used to confirm a fusion of the VAPB and CDH12 genes. The fusion of the VAPB and CDH12 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VAPB-CDH12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-RERE | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-REOR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-REGO | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-REGR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-REAQ | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-ORRE | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-OROR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-ORGO | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-ORAQ | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GORE | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GOOR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GOGO | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GOGR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GOAQ | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GRRE | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GROR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GRGO | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GRGR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-GRAQ | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-AQRE | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-AQOR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-AQGO | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-AQGR | 20 (40 μL) | 200 μL |
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| VAPB-CDH12-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH12 Gene Summary
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 12
Chromosome: CHR5: 21750972 -22853731
Locus: 5p14.3
VAPB Gene Summary
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
Gene Name: VAMP Associated Protein B And C
Chromosome: CHR20: 56964174 -57026156
Locus: 20q13.32
Gene Diseases
The VAPB CDH12 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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