SEARCH OUR PRODUCT CATALOG

VIM-CLCN3 Fusion FISH Probe

The VIM-CLCN3 Fusion FISH Probe is used to confirm a fusion of the VIM and CLCN3 genes. The fusion of the VIM and CLCN3 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
VIM-CLCN3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
VIM-CLCN3-20-RERE 20 (40 μL) 200 μL
VIM-CLCN3-20-REOR 20 (40 μL) 200 μL
VIM-CLCN3-20-REGO 20 (40 μL) 200 μL
VIM-CLCN3-20-REGR 20 (40 μL) 200 μL
VIM-CLCN3-20-REAQ 20 (40 μL) 200 μL
VIM-CLCN3-20-ORRE 20 (40 μL) 200 μL
VIM-CLCN3-20-OROR 20 (40 μL) 200 μL
VIM-CLCN3-20-ORGO 20 (40 μL) 200 μL
VIM-CLCN3-20-ORAQ 20 (40 μL) 200 μL
VIM-CLCN3-20-GORE 20 (40 μL) 200 μL
VIM-CLCN3-20-GOOR 20 (40 μL) 200 μL
VIM-CLCN3-20-GOGO 20 (40 μL) 200 μL
VIM-CLCN3-20-GOGR 20 (40 μL) 200 μL
VIM-CLCN3-20-GOAQ 20 (40 μL) 200 μL
VIM-CLCN3-20-GRRE 20 (40 μL) 200 μL
VIM-CLCN3-20-GROR 20 (40 μL) 200 μL
VIM-CLCN3-20-GRGO 20 (40 μL) 200 μL
VIM-CLCN3-20-GRGR 20 (40 μL) 200 μL
VIM-CLCN3-20-GRAQ 20 (40 μL) 200 μL
VIM-CLCN3-20-AQRE 20 (40 μL) 200 μL
VIM-CLCN3-20-AQOR 20 (40 μL) 200 μL
VIM-CLCN3-20-AQGO 20 (40 μL) 200 μL
VIM-CLCN3-20-AQGR 20 (40 μL) 200 μL
VIM-CLCN3-20-AQAQ 20 (40 μL) 200 μL

CLCN3 Gene Summary

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Name: Chloride Voltage-gated Channel 3

Chromosome: CHR4: 170541671 -170644338

Locus: 4q33

VIM Gene Summary

This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]

Gene Name: Vimentin

Chromosome: CHR10: 17270257 -17279592

Locus: 10p13

Gene Diseases

The VIM CLCN3 Fusion has been associated with the following diseases:

Disease Name
Adrenocortical Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.