VIM-DNM1L Fusion FISH Probe
The VIM-DNM1L Fusion FISH Probe is used to confirm a fusion of the VIM and DNM1L genes. The fusion of the VIM and DNM1L genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VIM-DNM1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-RERE | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-REOR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-REGO | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-REGR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-REAQ | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-ORRE | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-OROR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-ORGO | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GORE | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GOOR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GOGO | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GOGR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GRRE | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GROR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GRGO | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GRGR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-AQRE | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-AQOR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-AQGO | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-AQGR | 20 (40 μL) | 200 μL |
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| VIM-DNM1L-20-AQAQ | 20 (40 μL) | 200 μL |
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VIM Gene Summary
This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]
Gene Name: Vimentin
Chromosome: CHR10: 17270257 -17279592
Locus: 10p13
DNM1L Gene Summary
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Gene Name: Dynamin 1 Like
Chromosome: CHR12: 32832136 -32898584
Locus: 12p11.21
Gene Diseases
The VIM DNM1L Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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