VNN3-PTPRK Fusion FISH Probe
The VNN3-PTPRK Fusion FISH Probe is used to confirm a fusion of the VNN3 and PTPRK genes. The fusion of the VNN3 and PTPRK genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VNN3-PTPRK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-RERE | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-REOR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-REGO | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-REGR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-REAQ | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-ORRE | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-OROR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-ORGO | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-ORAQ | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GORE | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GOOR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GOGO | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GOGR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GOAQ | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GRRE | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GROR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GRGO | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GRGR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-GRAQ | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-AQRE | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-AQOR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-AQGO | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-AQGR | 20 (40 μL) | 200 μL |
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| VNN3-PTPRK-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRK Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type K
Chromosome: CHR6: 128289923 -128841870
Locus: 6q22.33
VNN3 Gene Summary
This gene is the central gene in a cluster of three vanin genes on chromosome 6q23-q24. Extensive alternative splicing has been described; the two most common variants are represented as RefSeqs. [provided by RefSeq, Apr 2014]
Gene Name: Vanin 3
Chromosome: CHR6: 133043925 -133055904
Locus: 6q23.2
Gene Diseases
The VNN3 PTPRK Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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