WRN-NRG1 Fusion FISH Probe
The WRN-NRG1 Fusion FISH Probe is used to confirm a fusion of the WRN and NRG1 genes. The fusion of the WRN and NRG1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WRN-NRG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-RERE | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-REOR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-REGO | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-REGR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-REAQ | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-ORRE | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-OROR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-ORGO | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GORE | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GOOR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GOGO | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GOGR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GRRE | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GROR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GRGO | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GRGR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-AQRE | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-AQOR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-AQGO | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-AQGR | 20 (40 μL) | 200 μL |
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| WRN-NRG1-20-AQAQ | 20 (40 μL) | 200 μL |
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NRG1 Gene Summary
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Gene Name: Neuregulin 1
Chromosome: CHR8: 31497267 -32600770
Locus: 8p12
WRN Gene Summary
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Gene Name: Werner Syndrome RecQ Like Helicase
Chromosome: CHR8: 30890777 -31031277
Locus: 8p12
Gene Diseases
The WRN NRG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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