XBP1-KLK2 Fusion FISH Probe
The XBP1-KLK2 Fusion FISH Probe is used to confirm a fusion of the XBP1 and KLK2 genes. The fusion of the XBP1 and KLK2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| XBP1-KLK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-RERE | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-REOR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-REGO | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-REGR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-REAQ | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-ORRE | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-OROR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-ORGO | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GORE | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GOOR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GOGO | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GOGR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GRRE | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GROR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GRGO | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GRGR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-AQRE | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-AQOR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-AQGO | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-AQGR | 20 (40 μL) | 200 μL |
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| XBP1-KLK2-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK2 Gene Summary
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Kallikrein Related Peptidase 2
Chromosome: CHR19: 51376688 -51383823
Locus: 19q13.33
XBP1 Gene Summary
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Gene Name: X-box Binding Protein 1
Chromosome: CHR22: 29190547 -29196560
Locus: 22q12
Gene Diseases
The XBP1 KLK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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