YWHAB-BCL2L1 Fusion FISH Probe
The YWHAB-BCL2L1 Fusion FISH Probe is used to confirm a fusion of the YWHAB and BCL2L1 genes. The fusion of the YWHAB and BCL2L1 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YWHAB-BCL2L1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-RERE | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-REOR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-REGO | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-REGR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-REAQ | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-ORRE | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-OROR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-ORGO | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-ORAQ | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GORE | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GOOR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GOGO | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GOGR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GOAQ | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GRRE | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GROR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GRGO | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GRGR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-GRAQ | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-AQRE | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-AQOR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-AQGO | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-AQGR | 20 (40 μL) | 200 μL |
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| YWHAB-BCL2L1-20-AQAQ | 20 (40 μL) | 200 μL |
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BCL2L1 Gene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
Gene Name: BCL2 Like 1
Chromosome: CHR20: 30252260 -30310656
Locus: 20q11.21
YWHAB Gene Summary
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Beta
Chromosome: CHR20: 43514343 -43537161
Locus: 20q13.12
Gene Diseases
The YWHAB BCL2L1 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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