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YWHAE-INPP5K Fusion FISH Probe

The YWHAE-INPP5K Fusion FISH Probe is used to confirm a fusion of the YWHAE and INPP5K genes. The fusion of the YWHAE and INPP5K genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
YWHAE-INPP5K-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
YWHAE-INPP5K-20-RERE 20 (40 μL) 200 μL
YWHAE-INPP5K-20-REOR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-REGO 20 (40 μL) 200 μL
YWHAE-INPP5K-20-REGR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-REAQ 20 (40 μL) 200 μL
YWHAE-INPP5K-20-ORRE 20 (40 μL) 200 μL
YWHAE-INPP5K-20-OROR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-ORGO 20 (40 μL) 200 μL
YWHAE-INPP5K-20-ORAQ 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GORE 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GOOR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GOGO 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GOGR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GOAQ 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GRRE 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GROR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GRGO 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GRGR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-GRAQ 20 (40 μL) 200 μL
YWHAE-INPP5K-20-AQRE 20 (40 μL) 200 μL
YWHAE-INPP5K-20-AQOR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-AQGO 20 (40 μL) 200 μL
YWHAE-INPP5K-20-AQGR 20 (40 μL) 200 μL
YWHAE-INPP5K-20-AQAQ 20 (40 μL) 200 μL

YWHAE Gene Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Epsilon

Chromosome: CHR17: 1247833 -1303556

Locus: 17p13.3

INPP5K Gene Summary

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Gene Name: Inositol Polyphosphate-5-phosphatase K

Chromosome: CHR17: 1397870 -1420182

Locus: 17p13.3

Gene Diseases

The YWHAE INPP5K Fusion has been associated with the following diseases:

Disease Name
Colon Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.