ZBTB20-CLDN11 Fusion FISH Probe
The ZBTB20-CLDN11 Fusion FISH Probe is used to confirm a fusion of the ZBTB20 and CLDN11 genes. The fusion of the ZBTB20 and CLDN11 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZBTB20-CLDN11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-RERE | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-REOR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-REGO | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-REGR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-REAQ | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-ORRE | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-OROR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-ORGO | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GORE | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GOOR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GOGO | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GOGR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GRRE | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GROR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GRGO | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GRGR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-AQRE | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-AQOR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-AQGO | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-AQGR | 20 (40 μL) | 200 μL |
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| ZBTB20-CLDN11-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN11 Gene Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]
Gene Name: Claudin 11
Chromosome: CHR3: 170136652 -170152479
Locus: 3q26.2
ZBTB20 Gene Summary
This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
Gene Name: Zinc Finger And BTB Domain Containing 20
Chromosome: CHR3: 114056946 -114866127
Locus: 3q13.31
Gene Diseases
The ZBTB20 CLDN11 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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