ZCCHC8-RSRC2 Fusion FISH Probe
The ZCCHC8-RSRC2 Fusion FISH Probe is used to confirm a fusion of the ZCCHC8 and RSRC2 genes. The fusion of the ZCCHC8 and RSRC2 genes has been associated with Breast Invasive Carcinoma, Uterine Corpus Endometrial Carcinoma, Kidney Renal Clear Cell Carcinoma, Skin Cutaneous Melanoma, Bladder Urothelial Carcinoma, Head And Neck Squamous Cell Carcinoma , Uterine Corpus Endometrial Carcinoma, Brain Lower Grade Glioma, Esophageal Carcinoma, Pancreatic Adenocarcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZCCHC8-RSRC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-RERE | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-REOR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-REGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-REGR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-OROR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GORE | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GROR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZCCHC8-RSRC2-20-AQAQ | 20 (40 μL) | 200 μL |
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ZCCHC8 Gene Summary
This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]
Gene Name: Zinc Finger CCHC-type Containing 8
Chromosome: CHR12: 122956145 -122985543
Locus: 12q24.31
RSRC2 Gene Summary
The Arginine And Serine Rich Coiled-coil 2 (RSRC2) gene is located on chr12 :122989189-123011560 at 12q24.31.
Gene Name: Arginine And Serine Rich Coiled-coil 2
Chromosome: CHR12: 122989189 -123011560
Locus: 12q24.31
Gene Diseases
The ZCCHC8 RSRC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Kidney Renal Clear Cell Carcinoma |
| Skin Cutaneous Melanoma |
| Bladder Urothelial Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Brain Lower Grade Glioma |
| Esophageal Carcinoma |
| Pancreatic Adenocarcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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