ZNF3-MCM7 Fusion FISH Probe
The ZNF3-MCM7 Fusion FISH Probe is used to confirm a fusion of the ZNF3 and MCM7 genes. The fusion of the ZNF3 and MCM7 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF3-MCM7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF3-MCM7-20-AQAQ | 20 (40 μL) | 200 μL |
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MCM7 Gene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Minichromosome Maintenance Complex Component 7
Chromosome: CHR7: 99690403 -99699427
Locus: 7q22.1
ZNF3 Gene Summary
The Zinc Finger Protein 3 (ZNF3) gene is located on chr7 :99661652-99679371 at 7q22.1.
Gene Name: Zinc Finger Protein 3
Chromosome: CHR7: 99661652 -99679371
Locus: 7q22.1
Gene Diseases
The ZNF3 MCM7 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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