ZNF709-MAN2B1 Fusion FISH Probe
The ZNF709-MAN2B1 Fusion FISH Probe is used to confirm a fusion of the ZNF709 and MAN2B1 genes. The fusion of the ZNF709 and MAN2B1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF709-MAN2B1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF709-MAN2B1-20-AQAQ | 20 (40 μL) | 200 μL |
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MAN2B1 Gene Summary
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Gene Name: Mannosidase Alpha Class 2B Member 1
Chromosome: CHR19: 12757321 -12777591
Locus: 19p13.13
ZNF709 Gene Summary
The Zinc Finger Protein 709 (ZNF709) gene is located on chr19 :12571997-12595632 at 19p13.2.
Gene Name: Zinc Finger Protein 709
Chromosome: CHR19: 12571997 -12595632
Locus: 19p13.2
Gene Diseases
The ZNF709 MAN2B1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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