ACHE FISH Probe
The ACHE FISH probe is designed to hybridize to the ACHE gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACHE-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ACHE-20-RE | 20 (40 μL) | 200 μL |  |
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| ACHE-20-GO | 20 (40 μL) | 200 μL |  |
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| ACHE-20-GR | 20 (40 μL) | 200 μL |  |
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| ACHE-20-AQ | 20 (40 μL) | 200 μL |  |
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| ACHE-20-DIG | 20 (40 μL) | 200 μL |  |
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| ACHE-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ACHE
Gene Name: Acetylcholinesterase (Cartwright Blood Group)
Chromosome: CHR7: 100487614-100493541
Locus: 7q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ACHE FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ACHE-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping