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ACRDYS1 FISH Probe

The ACRDYS1 FISH probe is designed to hybridize to the ACRDYS1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PRKAR1A-20-OR  (Standard Design) 20 (40 μL) 200 μL
PRKAR1A-20-RE 20 (40 μL) 200 μL
PRKAR1A-20-GO 20 (40 μL) 200 μL
PRKAR1A-20-GR 20 (40 μL) 200 μL
PRKAR1A-20-AQ 20 (40 μL) 200 μL
PRKAR1A-20-DIG 20 (40 μL) 200 μL
PRKAR1A-20-BIO 20 (40 μL) 200 μL

Gene Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]

Gene Details

Gene Symbol: PRKAR1A

Gene Name: Protein Kinase CAMP-dependent Type I Regulatory Subunit Alpha

Chromosome: CHR17: 66508109-66528910

Locus: 17q24.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: ACRDYS1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PRKAR1A-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping