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ADAMTS-4 FISH Probe

The ADAMTS-4 FISH probe is designed to hybridize to the ADAMTS-4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ADAMTS4-20-OR  (Standard Design) 20 (40 μL) 200 μL
ADAMTS4-20-RE 20 (40 μL) 200 μL
ADAMTS4-20-GO 20 (40 μL) 200 μL
ADAMTS4-20-GR 20 (40 μL) 200 μL
ADAMTS4-20-AQ 20 (40 μL) 200 μL
ADAMTS4-20-DIG 20 (40 μL) 200 μL
ADAMTS4-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Gene Details

Gene Symbol: ADAMTS4

Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4

Chromosome: CHR1: 161159537-161168845

Locus: 1q23.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: ADAMTS-4 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ADAMTS4-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping