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AH FISH Probe

The AH FISH probe is designed to hybridize to the AH gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ACO1-20-OR  (Standard Design) 20 (40 μL) 200 μL
ACO1-20-RE 20 (40 μL) 200 μL
ACO1-20-GO 20 (40 μL) 200 μL
ACO1-20-GR 20 (40 μL) 200 μL
ACO1-20-AQ 20 (40 μL) 200 μL
ACO1-20-DIG 20 (40 μL) 200 μL
ACO1-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Gene Details

Gene Symbol: ACO1

Gene Name: Aconitase 1

Chromosome: CHR9: 32384600-32450832

Locus: 9p21.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: AH FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ACO1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping