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APO1 FISH Probe

The APO1 FISH probe is designed to hybridize to the APO1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FAS-20-OR  (Standard Design) 20 (40 μL) 200 μL
FAS-20-RE 20 (40 μL) 200 μL
FAS-20-GO 20 (40 μL) 200 μL
FAS-20-GR 20 (40 μL) 200 μL
FAS-20-AQ 20 (40 μL) 200 μL
FAS-20-DIG 20 (40 μL) 200 μL
FAS-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Gene Details

Gene Symbol: FAS

Gene Name: Fas Cell Surface Death Receptor

Chromosome: CHR10: 90750287-90775542

Locus: 10q23.31

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: APO1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: FAS-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping