APPL2 FISH Probe
The APPL2 FISH probe is designed to hybridize to the APPL2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APPL2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| APPL2-20-RE | 20 (40 μL) | 200 μL |  |
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| APPL2-20-GO | 20 (40 μL) | 200 μL |  |
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| APPL2-20-GR | 20 (40 μL) | 200 μL |  |
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| APPL2-20-AQ | 20 (40 μL) | 200 μL |  |
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| APPL2-20-DIG | 20 (40 μL) | 200 μL |  |
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| APPL2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Gene Details
Gene Symbol: APPL2
Gene Name: Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 2
Chromosome: CHR12: 105567074-105630008
Locus: 12q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APPL2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APPL2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping