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C4BR FISH Probe

The C4BR FISH probe is designed to hybridize to the C4BR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CR1-20-OR  (Standard Design) 20 (40 μL) 200 μL
CR1-20-RE 20 (40 μL) 200 μL
CR1-20-GO 20 (40 μL) 200 μL
CR1-20-GR 20 (40 μL) 200 μL
CR1-20-AQ 20 (40 μL) 200 μL
CR1-20-DIG 20 (40 μL) 200 μL
CR1-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: CR1

Gene Name: Complement C3b/C4b Receptor 1 (Knops Blood Group)

Chromosome: CHR1: 207669472-207815110

Locus: 1q32.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: C4BR FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: CR1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping