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CASP8-1 FISH Probe

The CASP8-1 FISH probe is designed to hybridize to the CASP8-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CASP8-20-OR  (Standard Design) 20 (40 μL) 200 μL
CASP8-20-RE 20 (40 μL) 200 μL
CASP8-20-GO 20 (40 μL) 200 μL
CASP8-20-GR 20 (40 μL) 200 μL
CASP8-20-AQ 20 (40 μL) 200 μL
CASP8-20-DIG 20 (40 μL) 200 μL
CASP8-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: CASP8

Gene Name: Caspase 8

Chromosome: CHR2: 202098165-202152434

Locus: 2q33.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: CASP8-1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: CASP8-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping