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D-LIMK1 FISH Probe

The D-LIMK1 FISH probe is designed to hybridize to the D-LIMK1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
LIMK1-20-OR  (Standard Design) 20 (40 μL) 200 μL
LIMK1-20-RE 20 (40 μL) 200 μL
LIMK1-20-GO 20 (40 μL) 200 μL
LIMK1-20-GR 20 (40 μL) 200 μL
LIMK1-20-AQ 20 (40 μL) 200 μL
LIMK1-20-DIG 20 (40 μL) 200 μL
LIMK1-20-BIO 20 (40 μL) 200 μL

Gene Summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

Gene Details

Gene Symbol: LIMK1

Gene Name: LIM Domain Kinase 1

Chromosome: CHR7: 73498106-73536855

Locus: 7q11.23

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: D-LIMK1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: LIMK1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping