SEARCH OUR PRODUCT CATALOG

DM18 FISH Probe

The DM18 FISH probe is designed to hybridize to the DM18 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
XBP1-20-OR  (Standard Design) 20 (40 μL) 200 μL
XBP1-20-RE 20 (40 μL) 200 μL
XBP1-20-GO 20 (40 μL) 200 μL
XBP1-20-GR 20 (40 μL) 200 μL
XBP1-20-AQ 20 (40 μL) 200 μL
XBP1-20-DIG 20 (40 μL) 200 μL
XBP1-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: XBP1

Gene Name: X-box Binding Protein 1

Chromosome: CHR22: 29190547-29196560

Locus: 22q12

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: DM18 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: XBP1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping