HMGA2 FISH Probe
The HMGA2 FISH probe is designed to hybridize to the HMGA2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
SKU | Test Kits | Buffer | Dye Color | Order Now |
---|---|---|---|---|
HMGA2-20-OR (Standard Design) | 20 (40 μL) | 200 μL | ||
HMGA2-20-RE | 20 (40 μL) | 200 μL | ||
HMGA2-20-GO | 20 (40 μL) | 200 μL | ||
HMGA2-20-GR | 20 (40 μL) | 200 μL | ||
HMGA2-20-AQ | 20 (40 μL) | 200 μL | ||
HMGA2-20-DIG | 20 (40 μL) | 200 μL | ||
HMGA2-20-BIO | 20 (40 μL) | 200 μL |
Gene Summary
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HMGA2
Gene Name: High Mobility Group AT-hook 2
Chromosome: CHR12: 66218239-66360071
Locus: 12q14.3
FISH Probe Protocols
Protocol, Procedure, or Form Name | Last Modified | Download |
---|
Epithelial-Myoepithelial Carcinoma Frequent Morphologic and Molecular Evidence of Preexisting Pleomorphic Adenoma, Common HRAS Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases
Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma
Hydropic leiomyoma: a distinct variant of leiomyoma closely related to HMGA2 overexpression
Metastasizing Pleomorphic Adenoma: Recurrent PLAG1/HMGA2 Rearrangements and Identification of a Novel HMGA2-TMTC2 Fusion
Giant Cell Carcinosarcoma of the Parotid Gland With a PLAG1 Translocation in Association With a Pleomorphic Adenoma With HMGA2 Translocation: A Case Report and Fluorescence In Situ Hybridization Study
Product Details
Product: HMGA2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HMGA2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping