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HNE FISH Probe

The HNE FISH probe is designed to hybridize to the HNE gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ELANE-20-OR  (Standard Design) 20 (40 μL) 200 μL
ELANE-20-RE 20 (40 μL) 200 μL
ELANE-20-GO 20 (40 μL) 200 μL
ELANE-20-GR 20 (40 μL) 200 μL
ELANE-20-AQ 20 (40 μL) 200 μL
ELANE-20-DIG 20 (40 μL) 200 μL
ELANE-20-BIO 20 (40 μL) 200 μL

Gene Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]

Gene Details

Gene Symbol: ELANE

Gene Name: Elastase, Neutrophil Expressed

Chromosome: CHR19: 852290-856246

Locus: 19p13.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: HNE FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ELANE-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping