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HSVI FISH Probe

The HSVI FISH probe is designed to hybridize to the HSVI gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HBB-3'HS1-20-OR  (Standard Design) 20 (40 μL) 200 μL
HBB-3'HS1-20-RE 20 (40 μL) 200 μL
HBB-3'HS1-20-GO 20 (40 μL) 200 μL
HBB-3'HS1-20-GR 20 (40 μL) 200 μL
HBB-3'HS1-20-AQ 20 (40 μL) 200 μL
HBB-3'HS1-20-DIG 20 (40 μL) 200 μL
HBB-3'HS1-20-BIO 20 (40 μL) 200 μL

Gene Summary

This element represents a DNase I hypersensitive site that is found approximately 20 kb downstream of the beta-globin gene cluster in erythroid cells. It has been shown to function as a scaffold attachment region, and it also has enhancer-blocking activity that is mediated by binding of the CTCF transcription factor. Chromosome conformation capture assays indicate that it is an integral part of the beta-globin active chromatin hub in erythroid cells, where it undergoes looping interactions with the beta-globin locus control region (LCR) and active beta-globin gene promoters. A mutation in this hypersensitive site may be associated with beta-thalassemia intermedia. This hypersensitive site is located in a region that is deleted in some beta-thalassemias, including several hereditary persistence of fetal hemoglobin (HPFH) deletions. [provided by RefSeq, Jul 2015]

Gene Details

Gene Symbol: HBB-3'HS1

Gene Name: Beta-globin 3' Hypersensitive Site 1

Locus: 11p15

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: HSVI FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: HBB-3'HS1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping