KDELR2 FISH Probe
The KDELR2 FISH probe is designed to hybridize to the KDELR2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KDELR2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| KDELR2-20-RE | 20 (40 μL) | 200 μL |  |
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| KDELR2-20-GO | 20 (40 μL) | 200 μL |  |
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| KDELR2-20-GR | 20 (40 μL) | 200 μL |  |
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| KDELR2-20-AQ | 20 (40 μL) | 200 μL |  |
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| KDELR2-20-DIG | 20 (40 μL) | 200 μL |  |
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| KDELR2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: KDELR2
Gene Name: KDEL Endoplasmic Reticulum Protein Retention Receptor 2
Chromosome: CHR7: 6500711-6523849
Locus: 7p22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KDELR2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KDELR2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping