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LIMK-2 FISH Probe

The LIMK-2 FISH probe is designed to hybridize to the LIMK-2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
LIMK2-20-OR  (Standard Design) 20 (40 μL) 200 μL
LIMK2-20-RE 20 (40 μL) 200 μL
LIMK2-20-GO 20 (40 μL) 200 μL
LIMK2-20-GR 20 (40 μL) 200 μL
LIMK2-20-AQ 20 (40 μL) 200 μL
LIMK2-20-DIG 20 (40 μL) 200 μL
LIMK2-20-BIO 20 (40 μL) 200 μL

Gene Summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: LIMK2

Gene Name: LIM Domain Kinase 2

Chromosome: CHR22: 31608249-31676066

Locus: 22q12.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: LIMK-2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: LIMK2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping