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LIT1 FISH Probe

The LIT1 FISH probe is designed to hybridize to the LIT1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
KCNQ1OT1-20-OR  (Standard Design) 20 (40 μL) 200 μL
KCNQ1OT1-20-RE 20 (40 μL) 200 μL
KCNQ1OT1-20-GO 20 (40 μL) 200 μL
KCNQ1OT1-20-GR 20 (40 μL) 200 μL
KCNQ1OT1-20-AQ 20 (40 μL) 200 μL
KCNQ1OT1-20-DIG 20 (40 μL) 200 μL
KCNQ1OT1-20-BIO 20 (40 μL) 200 μL

Gene Summary

Human chromosomal region 11p15.5 contains two clusters of epigenetically-regulated genes that are expressed from only one chromosome in a parent-of-origin manner. Each cluster, or imprinted domain, is regulated by a functionally independent imprinting control region (ICR). The human CDKN1C/KCNQ1OT1 domain is regulated by an ICR located in an intron of KCNQ1, and contains at least eight genes that are expressed exclusively or preferentially from the maternally-inherited allele. The DNA of the ICR is specifically methylated on the maternally-inherited chromosome, and unmethylated on the paternally-inherited chromosome. The ICR contains the promoter of the KCNQ1OT1 gene that is exclusively expressed from the paternal allele. The KCNQ1OT1 transcript is the antisense to the KCNQ1 gene and is a unspliced long non-coding RNA. It interacts with chromatin and regulates transcription of multiple target genes through epigenetic modifications. The transcript is abnormally expressed from both chromosomes in most patients with Beckwith-Wiedemann syndrome, and the transcript also plays an important role in colorectal carcinogenesis. [provided by RefSeq, Apr 2012]

Gene Details

Gene Symbol: KCNQ1OT1

Gene Name: KCNQ1 Opposite Strand/antisense Transcript 1 (non-protein Coding)

Chromosome: CHR11: 2661767-2721228

Locus: 11p15.5

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: LIT1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: KCNQ1OT1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping