MAFK FISH Probe
The MAFK FISH probe is designed to hybridize to the MAFK gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAFK-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MAFK-20-RE | 20 (40 μL) | 200 μL |  |
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| MAFK-20-GO | 20 (40 μL) | 200 μL |  |
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| MAFK-20-GR | 20 (40 μL) | 200 μL |  |
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| MAFK-20-AQ | 20 (40 μL) | 200 μL |  |
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| MAFK-20-DIG | 20 (40 μL) | 200 μL |  |
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| MAFK-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]
Gene Details
Gene Symbol: MAFK
Gene Name: MAF BZIP Transcription Factor K
Chromosome: CHR7: 1570367-1582679
Locus: 7p22.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MAFK FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MAFK-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping