SEARCH OUR PRODUCT CATALOG

FISH Probe Products & Services
Request More Information

NFIB FISH Probe

The NFIB FISH probe is designed to hybridize to the NFIB gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
NFIB-20-OR  (Standard Design) 20 (40 μL) 200 μL
NFIB-20-RE 20 (40 μL) 200 μL
NFIB-20-GO 20 (40 μL) 200 μL
NFIB-20-GR 20 (40 μL) 200 μL
NFIB-20-AQ 20 (40 μL) 200 μL
NFIB-20-DIG 20 (40 μL) 200 μL
NFIB-20-BIO 20 (40 μL) 200 μL

Gene Summary

The Nuclear Factor I B (NFIB) gene is located on chr9:14081841 -14398982 at 9p23-p22.3.

Gene Details

Gene Symbol: NFIB

Gene Name: Nuclear Factor I B

Chromosome: CHR9: 14081841-14398982

Locus: 9p23-p22.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland

Adenoid cystic carcinoma (ACC) is a common salivary gland malignancy. The malignancy is associated with gene fusions between MYB, MYBL1, and NFIB. FISH analysis was used to evaluate any rearrangements in these genes with the use of our break apart probes. It was found through FISH that MYB aberrations were preserved between primary tumors and metastases. Additionally, MYB and NFIB aberrations are preserved in ACC metastatic lesions.
Read More

Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma

Lacrimal gland tumors are histologically similar to salivary gland tumors. In the salivary glands, pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (ca_ex_PA) are both characterized by PLAG1 and HMGA2 gene rearrangements. However, it is not known if these rearrangements are present in lacrimal gland PA and ca_ex_PA. FISH analysis was done with our PLAG1, HMGA2, and NFIB break apart probes. It was found that rearrangements were frequent in the tested lacrimal glands and that testing for the rearrangement can help in distinguishing lacrimal gland PA and ca_ex_PA from de novo carcinomas.
Read More

MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study

Adenoid cystic carcinoma (ACC) is a frequent malignancy of the salivary gland that is challenging due to an unpredictable clinical course. In hopes of improving this predictability, the association of microRNA with prognostic value in ACC is under study. Along with microRNA tests, FISH analysis was performed with various break apart probes, including our MYLB1 and NFIB probes, to look for any fusion or rearrangement. It was found that several microRNAs were associated with the outcome of ACC and that the most unifying feature of ACC is still involvement of the MYB gene.
Read More

Molecular features of adenoid cystic carcinoma with an emphasis on microRNA expression

Adenoid cystic carcinoma (ACC) is a subtype of salivary gland tumor that can have a poor prognosis. ACC can also be present in lacrimal glands and the breasts with the tumors appearing to be seemingly identical to one another. The phenotypes, genetics, and microRNA expression of ACC in the salivary glands, lacrimal glands, and breasts was characterized in order to better understand the differences between them. Among other characterization tools, FISH analysis was performed with several break apart probes, including our MYBL1 and NFIB probes. The results seemed to indicate that microRNA has value in distinguishing between the tumors.
Read More

Product Details

Product: NFIB FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: NFIB-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping