NFKB1 FISH Probe
The NFKB1 FISH probe is designed to hybridize to the NFKB1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NFKB1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NFKB1-20-RE | 20 (40 μL) | 200 μL |  |
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| NFKB1-20-GO | 20 (40 μL) | 200 μL |  |
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| NFKB1-20-GR | 20 (40 μL) | 200 μL |  |
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| NFKB1-20-AQ | 20 (40 μL) | 200 μL |  |
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| NFKB1-20-DIG | 20 (40 μL) | 200 μL |  |
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| NFKB1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Details
Gene Symbol: NFKB1
Gene Name: Nuclear Factor Kappa B Subunit 1
Chromosome: CHR4: 103422485-103538459
Locus: 4q24
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NFKB1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NFKB1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping