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PAX5 FISH Probe

The PAX5 FISH probe is designed to hybridize to the PAX5 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PAX5-20-OR  (Standard Design) 20 (40 μL) 200 μL
PAX5-20-RE 20 (40 μL) 200 μL
PAX5-20-GO 20 (40 μL) 200 μL
PAX5-20-GR 20 (40 μL) 200 μL
PAX5-20-AQ 20 (40 μL) 200 μL
PAX5-20-DIG 20 (40 μL) 200 μL
PAX5-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Gene Details

Gene Symbol: PAX5

Gene Name: Paired Box 5

Chromosome: CHR9: 36838530-37034476

Locus: 9p13.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Diffuse large B-cell lymphoma carrying t(9;14)(p13;q32)/PAX5-immunoglobulin heavy chain gene is characterized by nuclear positivity of MUM1 and PAX5 by immunohistochemistry

PAX5 encodes a transcription factor that helps regulate B-cell development. Rearrangements of the gene have been found in several low-grade B-cell tumors, including diffuse large B-cell lymphoma (DLBCL), where it’s frequently found fused to IGH. This study examined PAX5 expression in 4 DLBCL patients harboring PAX5/IGH fusions. Our PAX5 break-apart probe was used to confirm these fusions.

Product Details

Product: PAX5 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PAX5-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping