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PMS2 FISH Probe

The PMS2 FISH probe is designed to hybridize to the PMS2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PMS2-20-OR  (Standard Design) 20 (40 μL) 200 μL
PMS2-20-RE 20 (40 μL) 200 μL
PMS2-20-GO 20 (40 μL) 200 μL
PMS2-20-GR 20 (40 μL) 200 μL
PMS2-20-AQ 20 (40 μL) 200 μL
PMS2-20-DIG 20 (40 μL) 200 μL
PMS2-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]

Gene Details

Gene Symbol: PMS2

Gene Name: PMS1 Homolog 2, Mismatch Repair System Component

Chromosome: CHR7: 6012869-6048737

Locus: 7p22.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: PMS2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PMS2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping