PRKAR2B FISH Probe
The PRKAR2B FISH probe is designed to hybridize to the PRKAR2B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRKAR2B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| PRKAR2B-20-RE | 20 (40 μL) | 200 μL |  |
|
| PRKAR2B-20-GO | 20 (40 μL) | 200 μL |  |
|
| PRKAR2B-20-GR | 20 (40 μL) | 200 μL |  |
|
| PRKAR2B-20-AQ | 20 (40 μL) | 200 μL |  |
|
| PRKAR2B-20-DIG | 20 (40 μL) | 200 μL |  |
|
| PRKAR2B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PRKAR2B
Gene Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Beta
Chromosome: CHR7: 106685177-106802256
Locus: 7q22.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: PRKAR2B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PRKAR2B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping