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TRIM11 Break Apart FISH Probe

Empire Genomics’ TRIM11 Break Apart FISH Probe is designed to flank the TRIM11 gene and is typically used for detecting TRIM11 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
TRIM11BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
TRIM11BA-20-AQOR 20 (40 μL) 200 μL
TRIM11BA-20-GOGR 20 (40 μL) 200 μL
TRIM11BA-20-GORE 20 (40 μL) 200 μL
TRIM11BA-20-GRGO 20 (40 μL) 200 μL
TRIM11BA-20-GRRE 20 (40 μL) 200 μL
TRIM11BA-20-ORGR 20 (40 μL) 200 μL
TRIM11BA-20-REGO 20 (40 μL) 200 μL
TRIM11BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: TRIM11

Gene Name: Tripartite Motif Containing 11

Chromosome: CHR1: 228581376-228594517

Locus: 1q42.13

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Cutaneous Melanocytoma With CRTC1-TRIM11 Fusion

Primary intradermal nodular unpigmented tumors in several patients were analyzed for genetic similarities. It was thought that the CRTC1-TRIM11 fusion would be a novel genetic marker for the tumor. FISH analysis was used with our TRIM11 break apart probe to confirm the presence of the gene fusion. Other FISH analysis was done before TRIM11 as "diagnostic molecular testing". Of the five tumors under analysis, each of them did contain the CRTC1-TRIM11 fusion, which was concluded to be specific to the type of nodular tumor being studied.
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CRTC1-TRIM11 Fusion Defined Melanocytic Tumors: A Series of Four Cases

Recently, a new entity of cutaneous melanocytic tumor morphologically resembling clear cell sarcoma was identified in 5 adult patients, characterized by CRTC1-TRIM11 gene fusion. In this study, 4 new cases of this malignancy were analyzed using IHC, RNA sequencing, and FISH. TRIM11 rearrangement was verified using Empire Genomics’ break-apart TRIM11 FISH probe. Tumors were all positive for SOX10 and MiTF, mostly positive for S100 protein, and only focally expressed other melanocytic biomarkers (Melan-A and HMB45).
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Product Details

Product: TRIM11 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: TRIM11-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping