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VHLL FISH Probe

The VHLL FISH probe is designed to hybridize to the VHLL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
VHLL-20-OR  (Standard Design) 20 (40 μL) 200 μL
VHLL-20-OR 20 (40 μL) 200 μL
VHLL-20-OR 20 (40 μL) 200 μL
VHLL-20-OR 20 (40 μL) 200 μL
VHLL-20-OR 20 (40 μL) 200 μL
VHLL-20-OR 20 (40 μL) 200 μL
VHLL-20-OR 20 (40 μL) 200 μL

Gene Summary

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010]

Gene Details

Gene Symbol: VHLL

Gene Name: VHL Like

Chromosome: CHR1: 156268414-156269428

Locus: 1q22

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: VHLL FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: VHLL-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping