19p19q FISH Probe
Empire Genomics’ 19p19q FISH probe is designed to detect amplifications and deletions in the 19p13.2/19q13.3 chromosomal regions. The probe comes labeled in green and orange, but can be customized to meet your needs. A normal 19p19q signal will show two sets of split orange and green signals. An abnormal sample will result in either a missing orange signal, indicating loss of 19q, or a missing green signal, indicating loss of 19p.
Gene Background: Gliomas are tumors of the brain and spinal cord that arise in the glial cells. Astrocytomas and oligodendrogliomas are the two most common types of glioma, accounting for about 40% of all CNS tumors and more than 60% of primary brain cancers.1 Losses of 19q are found in approximately 80% of oligodendrogliomas, two-thirds of anaplastic oligodendrogliomas, and, to varying frequencies, in certain subsets of oligoastrocytomas and anaplastic oligoastrocytomas.2 Most of these losses result from an unbalanced t(1;19)(q10;p10) translocation. Deletion of 19q has also been shown to occur in a subset of extraventricular neurocytomas.3
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|19p19q-20-GROR (Standard Design)||20 (40 μL)||200 μL|