NTRK3 Break Apart FISH Probe

Empire Genomics' NTRK3 Break Apart FISH probe is designed to detect rearrangements of the NTRK3 gene at chromosomal region 15q25.3. The probe comes labeled in orange and green, but can be customized to meet your needs. A normal signal pattern will show two sets of overlapping orange and green signals. An abnormal pattern will show at least one set of split orange and green signals, indicating NTRK3 translocation.

Gene Background: NTRK3 encodes the TrkC receptor, a glycoprotein expressed in the human hippocampus, cerebral cortex and in the granular cell layer of the cerebellum. NTRK3 rearrangements have been detected in a variety of malignancies, including glioblastoma, fibrosarcoma, thyroid cancer, and acute myeloid leukemia. Many of these translocations result in fusion with ETV6; the resulting fusion gene, which differs in its breakpoints depending on the cancer type, has been shown to be an oncogenic driver in its associated diseases.

Source: Amatu A, et al. (2016) ESMO open 1.2: e000023.

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SKU Test Kits Buffer Dye Color Order Now
NTRK3BA-20-GOGR 20 (40μL) 200 μL
NTRK3BA-20-ORGR 20 (40μL) 200 μL
NTRK3BA-20-REGO 20 (40μL) 200 μL
NTRK3BA-20-GRRE 20 (40μL) 200 μL
NTRK3BA-20-REGR 20 (40μL) 200 μL
NTRK3BA-20-REAQ 20 (40μL) 200 μL
NTRK3BA-20-GROR 20 (40μL) 200 μL
NTRK3BA-20-GRGO 20 (40μL) 200 μL