IGF2BP3 FISH Probe
The Insulin-Like Growth Factor 2 MRNA Binding Protein 3 (IGF2BP3) gene, located at 7p15.3, is an oncofetal protein that has a negative prognostic influence that is re-activated in a variety of cancers. IGF2BP3 is expressed in ~98% of serous carcinomas. It is also associated with ovarian clear cell carcinoma, Pilomyxoid astrocytoma (PMA), most recently categorized as a pediatric brain tumor, as well as adenocarcinoma in situ which is the precursor to cervical cancer.
Empire Genomics has developed a IGF2BP3 FISH Probe which can be used to detect IGF2BP3 gene aneusomy. The probe comes labeled in green, and you may also choose to customize the probe to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGF2BP3-20-GR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGF2BP3-20-RE | 20 (40 μL) | 200 μL |
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| IGF2BP3-20-AQ | 20 (40 μL) | 200 μL |
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| IGF2BP3-20-OR | 20 (40 μL) | 200 μL |
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| IGF2BP3-20-GO | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: IGF2BP3
Gene Name: Insulin Like Growth Factor 2 MRNA Binding Protein 3
Chromosome: CHR7: 23349827-23509995
Locus: 7p15.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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