Genomic Products & Services

PD-L1 FISH Probe Panels

PD-L1, PD-L2, JAK2, & STAT3

Activity of the JAK-STAT pathway has been shown to increase the expression levels of PD-L1 in lymphoma. The JAK-STAT pathway is copy number dependent and this tri-color probe kit is designed to detect amplifications. The default colors of this probe have PD-L1 and PD-L2 labeled in red, JAK2 labeled in green, and STAT3 labeled in gold.

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PD-L1, PD-L2, & JAK2

Amplification of the PD-L1, PD-L2, and JAK2 genes in the 9p24.1 region have been reported in lymphomas, gastric cancer, and triple negative breast cancer. This dual-color probe comes with the PD-L1 and PD-L2 labeled in red, and JAK2 labeled in green.

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Overexpression of PD-L1 and PD-L2 can protect a tumor cell from an innate immune response, but new medications can effectively target cells overexpressing these genes. Our PD-L1, PD-L2, and Control 9 Dual Colored FISH probe can detect amplifications and rearrangements in these genes, leading to a better understanding of the tumor’s genomic profile.

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Understanding the PD-L1 profile of a tumor cell can open up treatment options that have recently become available. The probe comes labeled in orange and green, and you may also choose to customize the probe to meet your needs.

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The Chromosome 9 Control probe specifically hybridizes to 9q21, and is labeled using fluorescence in situ hybridization in green, red, orange, gold or aqua. The Chromosome 9 Control probe can act as a control when combined with a gene or region specific probe.

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To Speak To The FISH Probe Experts, Call 1-800-715-5880